1667
clinical study

Early-stage COVID-19 Pandemic Observations on Pulmonary Embolism Using Nationwide Multi-Institutional Data Harvesting

Materials & Methods

A Multi-institutional Data Harvesting (MIDH) method for retrospective, longitudinal observation of medical imaging utilization and reporting for computed tomography pulmonary angiograms (CTPA) (n=40,037) was conducted across 13 academic sites. Compared two 70-day observational periods, namely (i) a pre-pandemic control period from Nov. 25, 2019 to Feb. 2, 2020, and (ii) a period during the early COVID-19 pandemic from March 8, 2020 through May 16, 2020. Natural language processing (NLP) on final radiology reports served as the ground truth for identifying positive PE cases.

Results

Fewer CTPA exams were performed during the early COVID-19 pandemic than during the pre-pandemic period (9,806 vs. 12,106). The PE positivity rate was significantly higher during the early COVID-19 pandemic than during the pre-pandemic period (11.6 vs. 9.9%, p < 10−4). NLP accuracy of 98% based on a manual review of 2,400 radiology reports

Conclusions

The positivity of PE was significantly higher during the COVID era and fewer CTPA exams were performed. This MIDH method showed the successful scalability and ability of the Aidoc solution to overcome typical challenges of multi-institution data silos while maintaining a high level of accuracy in PE classification.

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Amalia Schreier

<p>Amalia Schreier serves as the Senior Vice President of Regulatory Affairs and Legal at Aidoc, guiding our company and product’s regulatory strategies and ensuring alignment with AI-focused medical device compliance requirements. Since her tenure began, she has streamlined our FDA clearance processes, emphasizing a meticulous approach that underscores our commitment to product and clinical quality.</p> <p>With a solid foundation from her legal background and leadership role in AI startup regulatory departments, Schreier brings invaluable insights and expertise to our regulatory framework. Prior to her tech world experience, she worked as a human-rights lawyer and legal policy scholar, with a BA and LLM in law from the Hebrew University of Jerusalem.</p>

Deepak Srikant

<p>Deepak Srikant is a global marketing executive with over 20 years of experience, specializing in the commercialization of medical devices and digital health solutions. He has a proven track record in driving growth, having led successful go-to-market strategies, product launches and market expansions across the U.S. and EMEA.</p> <p>Srikant’s expertise extends to upstream and downstream marketing, professional education and sales enablement. His leadership at companies such as Silk Road Medical (acquired by Boston Scientific) and Aptus Endosystems (acquired by Medtronic) has consistently resulted in revenue growth, enhanced customer retention and successful product adoption.</p> <p>Srikant holds an MBA from the Yale School of Management and a bachelor’s degree in mechanical engineering from Rensselaer Polytechnic Institute. Currently, he leads product marketing for Aidoc’s cardiovascular service line.</p>

Laci Costa

<p>Laci Costa is the Director of Neurovascular Product Marketing at Aidoc. She leads marketing and commercial strategy for the neuro AI portfolio of products. She has 16 years of experience working in the medical device and healthcare industry, with over 12 years dedicated to neurovascular solutions.</p> <p>Costa’s known for her expertise in the neurovascular industry, go-to-market experience with new technologies and upstream and downstream product marketing leadership. She’s held various leadership positions in product marketing, clinical education and professional affairs spanning across start-up organizations to large publicly traded companies.</p> <p>Costa holds a bachelor’s degree in psychology from the University of Oklahoma and an MBA from USC Marshall School of Business.</p>