The International Stroke Conference 2025, held from February 5–7 in Los Angeles, showcased significant developments in stroke research and treatment. A focal point of the conference was the presentation of data from multiple MeVO clinical studies, which evaluated the efficacy of endovascular thrombectomy (EVT) in patients with medium vessel occlusions (MeVOs). The role of AI solutions were also highlighted as an important element to advancing stroke care.
Three stroke thrombectomy trials were presented at ISC – all showed no improvement in functional outcomes, and the potential for harm, versus medical therapy alone in medium and distal vessel occlusions.
“Adding endovascular therapy to best medical therapy or usual care did not boost functional outcomes at 90 days in the DISTAL, ESCAPE-MeVO or DISCOUNT trials, with risks of mortality and symptomatic intracranial hemorrhage that were either similar or higher with the additional procedure,” noted an article from tctMD.
J Mocco, MD, MS, Senior Vice Chair of Neurosurgery and Director of the Cerebrovascular Center at Mount Sinai Health System, posted his thoughts following the results emphasizing that, “while thrombectomy has proven effective for large vessel occlusions (LVOs), smaller strokes may require a different approach. Future research will be key to determining the best treatment for various ischemic strokes.”
Aidoc’s Full Brain AI Solution can help surface suspected occlusions for both anterior and posterior occlusions in large and medium vessels. Regardless of how the patient is treated – with medical therapy only or medical therapy and EVT – Aidoc helps triage and prioritize these patients for care teams.
Given the narrow time window of opportunity for identifying eligible patients, the IV lytics workflow remains a crucial first step. Data indicates a 9-14% initial miss rate for strokes in emergency departments, which underscores the value of Aidoc’s AI Solutions in capturing more of these patients earlier.
In addition to Aidoc’s vessel occlusion algorithm, Aidoc’s aiOS™ identifies unexpected findings by analyzing all relevant CTAs, not just suspected stroke cases. This broader approach uncovers unforeseen findings, increasing treatment and intervention opportunities. The aiOS™ extracts metadata from scans, analyzes scans at the pixel level to identify all anatomy present, and then runs all relevant algorithms. Not tied to protocol, aiOS™ intelligent orchestration casts a wider net, looking for the unexpected and discovering critical findings beyond a specific protocol.
The integration of AI in stroke care, as exemplified by Aidoc’s Full Brain AI Solution, represents a promising advancement in the timely diagnosis and treatment of stroke patients. The International Stroke Conference 2025 highlighted both the challenges and innovations in stroke treatment. While the MeVO trial results call for a reassessment of EVT’s role in medium vessel occlusions, the transformative potential of AI in stroke triage, treatment, and prevention are paving the way for more personalized and efficient patient care.
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